Tranexamic Acid 100 mg/mL Injection is a sterile antifibrinolytic injectable solution widely used to prevent and control excessive bleeding in surgical, traumatic, obstetric, and medical settings. It is intended for intravenous administration by trained healthcare professionals in hospitals or controlled clinical environments where bleeding risk is high and rapid haemostatic control is required.

🧠 Mechanism of Action:

Tranexamic acid is a synthetic lysine analogue that works by competitively inhibiting the activation of plasminogen to plasmin, the enzyme responsible for fibrin clot degradation. By blocking plasmin binding sites on fibrin, tranexamic acid stabilises formed blood clots and prevents premature clot breakdown, thereby reducing bleeding without promoting new clot formation.

💉 Form, Packaging & Administration:

This formulation is supplied as a clear, colourless sterile solution containing 100 mg of tranexamic acid per mL. It is typically packaged in 5 mL or 10 mL ampoules or vials for slow intravenous injection or dilution prior to IV infusion. Administration rate and dosage depend on the indication, patient weight, renal function, and clinical scenario, and must be determined by a qualified clinician.

🩺 Primary Clinical Uses:

Control and prevention of bleeding in major surgeries (orthopaedic, cardiac, gynaecological, urological)

Management of post-partum haemorrhage (PPH)

Reduction of bleeding in trauma patients

Adjunctive therapy in dental procedures for patients with bleeding disorders

Treatment of menorrhagia and other hyperfibrinolytic conditions under medical supervision

⚠️ Important Safety & Precautions:

Tranexamic acid should be used cautiously in patients with a history of thromboembolic disease, renal impairment, or disseminated intravascular coagulation unless clearly indicated. Rapid IV administration may cause hypotension. Continuous monitoring and adherence to recommended dosing guidelines are essential to minimise the risk of adverse effects such as thrombosis or seizures at high doses.

🧰 Storage & Handling:

Store at controlled room temperature, protected from light and freezing. Do not use if the solution is discoloured or contains particulate matter. Maintain strict aseptic technique during preparation and administration and follow manufacturer labelling, product monographs, and applicable regulatory guidelines.

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